Fibroblast Growth Factor-18 (FGF-18) is a heparin-binding growth factor that is a member of the FGF family. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. FGF-18 plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. FGF-18 is required for normal ossification and bone development. It can also stimulate hepatic and intestinal proliferation.

產(chǎn)品簡(jiǎn)介

Species： Human 

Protein：Construction Expressed with an N-terminal Met. 

                     FGF-18 (Ala27-Arg199)

                    Accession # O76093 

 Purity ：> 95% as analyzed by SDS-PAGE

              > 95% as analyzed by HPLC 

Endotoxin Level ：< 0.2 EU/μg of protein by gel clotting method 

Biological Activity ：ED50 < 10.0 ng/ml, measured by a cell proliferation assay using 3T3 Cells, corresponding to a specific activity of > 1.0 × 105 units/mg. 

Expression System ：E. coli 

Apparent Molecular Weight ：~20.3 kDa, on SDS-PAGE under reducing conditions. 

Formulation： Lyophilized after extensive dialysis against PBS. 

Reconstitution： It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH?O up to 100 μg/ml. 

Storage & Stability ：Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. 

技術(shù)背景

Target Background： Fibroblast Growth Factor-18 (FGF-18) is a heparin-binding growth factor that is a member of the FGF family. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. FGF-18 plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. FGF-18 is required for normal ossification and bone development. It can also stimulate hepatic and intestinal proliferation. 

Synonyms： FGF18; Fibroblast Growth Factor-18; zFGF5; FGFI 

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.